December 27, 2024EBioMedicineOpen Access

Plasma lipidomics identified candidates with high diagnostic accuracy (AUC = 0.919, 95% CI 0.840-0.979) for screening MASH.

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Why the study?

Fat storage is closely associated with MASLD and MASH progression, suggesting adipose tissue metabolic homeostasis could be key in the onset and progression of MASH.

Population

n = 100 patients undergoing bariatric surgery

Comparison

MASH vs non-MASH controls

Design

Case-control observational research

Authors

HCHelena Castañé AJAndrea Jiménez-Franco AHAnna Hernández‐Aguilera

Discussion

Member takes

Overview

Supports lipidomic biomarkers for MASH screening; leaves open prospective validation before clinical adoption.

Structured PICO

Population

n = 100 patients undergoing bariatric surgery

Intervention

Multi-omics profiling (lipidomics, proteomics, transcriptomics) of liver, abdominal subcutaneous adipose tissue (SAT), omental visceral adipose tissue (VAT), and blood

Outcome

Identification of metabolic pathways and diagnostic biomarkers for metabolic dysfunction-associated steatohepatitis (MASH)surrogate

Multi-omics profiling reveals mitochondrial dysfunction in visceral adipose tissue of patients with obesity-associated MASH, and identifies plasma lipidomic candidates with high diagnostic accuracy for MASH screening.

Cite This Study

Castañé et al. (2024) studied this question.

synapsesocial.com/papers/69ffeb78b124fe581985af4a https://doi.org/10.1016/j.ebiom.2024.105532

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December 27, 2024EBioMedicineOpen Access

Plasma lipidomics identified candidates with high diagnostic accuracy (AUC = 0.919, 95% CI 0.840-0.979) for screening MASH.

View Full Paper

Ask AI

Bookmark

Why the study?

Fat storage is closely associated with MASLD and MASH progression, suggesting adipose tissue metabolic homeostasis could be key in the onset and progression of MASH.

Population

n = 100 patients undergoing bariatric surgery

Comparison

MASH vs non-MASH controls

Design

Case-control observational research

Authors

HCHelena Castañé AJAndrea Jiménez-Franco AHAnna Hernández‐Aguilera

Discussion

Member takes

Overview

Supports lipidomic biomarkers for MASH screening; leaves open prospective validation before clinical adoption.

Structured PICO

Population

n = 100 patients undergoing bariatric surgery

Intervention

Multi-omics profiling (lipidomics, proteomics, transcriptomics) of liver, abdominal subcutaneous adipose tissue (SAT), omental visceral adipose tissue (VAT), and blood

Outcome

Identification of metabolic pathways and diagnostic biomarkers for metabolic dysfunction-associated steatohepatitis (MASH)surrogate

Cite This Study

Castañé et al. (2024) studied this question.

synapsesocial.com/papers/69ffeb78b124fe581985af4a https://doi.org/10.1016/j.ebiom.2024.105532

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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