Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis

Nicolò Pernigoni; Elena Zagato; Arianna Calcinotto; Martina Troiani; Ricardo Pereira Mestre; Bianca Calì; Giuseppe Attanasio; Jacopo Troisi; Mirko Minini; Simone Mosole; Ajinkya Revandkar; Emiliano Pasquini; Angela Rita Elia; Daniela Bossi; Andrea Rinaldi; Pasquale Rescigno; Penny Flohr; Joanne Hunt; Antje Neeb; Lorenzo Buroni; Christina Guo; Jonathan Welti; Matteo Ferrari; Matteo Grioni; Josée Gauthier; Raad Z. Gharaibeh; Anna Palmisano; Gladys Martinetti Lucchini; Eugenia D’Antonio; Sara Merler; Marco Bolis; Fabio Grassi; Antonio Esposito; Matteo Bellone; Alberto Briganti; María Rescigno; Jean‐Philippe Theurillat; Christian Jobin; Silke Gillessen; Johann S. de Bono; Andrea Alimonti

doi:10.1126/science.abf8403

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Abstract

administration. These results reveal that the commensal gut microbiota contributes to endocrine resistance in CRPC by providing an alternative source of androgens.

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Pernigoni et al. (2021) studied this question.

synapsesocial.com/papers/6a000f5a4716aad0cc8591d8 https://doi.org/10.1126/science.abf8403

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Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis

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Abstract

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Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis

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