Immunohistological basis of the late gadolinium enhancement phenomenon in tako-tsubo cardiomyopathy
Why the study?
What is the histological basis of late gadolinium enhancement in patients with tako-tsubo cardiomyopathy?
Population
15 patients with tako-tsubo cardiomyopathy diagnosed by coronary angiography and ventriculography.
Comparison
Cardiac MRI within 24 h of admission and… vs LGE negative patients and control tissue.
Design
Cohort
Follow-up
14 days (IQR 11-14.5 days)
Authors
Discussion
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Member takes
Implication
LGE may mark reversible collagen-1 expansion in takotsubo cardiomyopathy; leaves open prognostic value and management implications.
Structured PICO
What is the histological basis of late gadolinium enhancement in patients with tako-tsubo cardiomyopathy?
P
Population
15 patients with tako-tsubo cardiomyopathy diagnosed by coronary angiography and ventriculography.
I
Intervention
Cardiac MRI within 24 h of admission and endomyocardial biopsies during acute phase and after recovery.
C
Comparator
LGE negative patients and control tissue.
O
Outcome
Content of fibrosis determined by immunohistochemical staining of collagen-1.surrogate
Late gadolinium enhancement in tako-tsubo cardiomyopathy is associated with a disproportionate, reversible increase in extracellular matrix (collagen-1) rather than irreversible fibrosis.
Cite This Study
Rolf et al. (2009) studied this question.