Why the study?
Does iterative Bayesian PK-guided dosing reduce perioperative FVIII concentrate consumption compared to standard dosing in haemophilia A patients undergoing elective surgery?
Does iterative Bayesian PK-guided dosing reduce perioperative FVIII concentrate consumption compared to standard dosing in haemophilia A patients undergoing elective surgery?
This study protocol outlines an RCT to determine if PK-guided dosing reduces FVIII concentrate consumption during surgery in haemophilia A patients.
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Planned RCT will test PK-guided FVIII dosing in surgical haemophilia A; leaves open whether it reduces perioperative consumption versus standard care.
Hazendonk et al. (2015) studied this question.
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