Sex-specific associations of sedentary behaviour and physical activity with placental and fetal IL-6 in pregnant women with obesity. Impact on neonatal adiposity in the DALI randomised controlled trial

Pedro Acosta‐Manzano; David J. Hill; Barbara Leopold‐Posch; Gernot Desoyé; Mireille N. M. van Poppel; David Simmons; Roland Devlieger; Sander Galjaard; Rosa Corcoy; Juan M. Adelantado; Fidelma Dunne; Jürgen Harreiter; Alexandra Kautzky-Willer; Peter Damm; Elisabeth R. Mathiesen; Dorte Møller Jensen; Lise-Lotte Andersen; Mette Tanvig; Annunziata Lapolla; Maria-Grazia Dalfra; Alessandra Bertolotto; Ewa Wender-Ozegowska; Agnieszka Zawiejska; Frank J Snoek; Judith G. M. Jelsma; Gernot Desoyé; Mireille N. M. van Poppel

doi:10.1016/j.diabres.2026.113292

Key Points

The aim is to examine how sedentary behaviour and physical activity impact placental IL-6 and subsequently neonatal adiposity in pregnant women with obesity.
Participants were randomized in the DALI trial.
Sedentary behaviour and physical activity levels were monitored and assessed.
IL-6 expression was measured in placentas of pregnant women.
Increased physical activity led to higher IL-6 expression in female placentas.
Reduced sedentary time correlated with elevated placental IL-6 levels.
Higher IL-6 expression was associated with lower fetal insulinemia and insulin resistance.

Implication

Randomized trial explores how sedentary behaviour and physical activity influence placental IL-6 and neonatal fat in obese women, suggesting important health implications.

Abstract

Reducing maternal sedentary time upregulates IL-6 expression in female placentas. Increasing physical activity also upregulates IL-6 expression in female placentas. Higher IL-6 expression relates to lower fetal insulinemia and insulin resistance. Lower fetal insulinemia and insulin resistance relate

Discussion

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Cite This Study

Acosta‐Manzano et al. (2026) studied this question.

synapsesocial.com/papers/6a00205ec8f74e3340f9b348 https://doi.org/10.1016/j.diabres.2026.113292

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Sex-specific associations of sedentary behaviour and physical activity with placental and fetal IL-6 in pregnant women with obesity. Impact on neonatal adiposity in the DALI randomised controlled trial

Key Points

Implication

Abstract

Discussion

Cite This Study

Sex-specific associations of sedentary behaviour and physical activity with placental and fetal IL-6 in pregnant women with obesity. Impact on neonatal adiposity in the DALI randomised controlled trial

Key Points

Implication

Abstract

Discussion

Cite This Study

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