What question did this study set out to answer?

This research aims to investigate the effects of LSD treatment on white matter changes in patients with major depression.

May 10, 2026Cell Reports Medicine2 citationsOpen Access

Neuroplastic white matter changes in patients with major depression following lysergic acid diethylamide treatment

MAMihai AvramInstitute for Integrative and Experimental Genomics AMAurore MenegauxKlinikum rechts der Isar FMFelix MüllerUniversity of Basel

Key Points

This research aims to investigate the effects of LSD treatment on white matter changes in patients with major depression.
Patients with major depression were administered moderate-to-high doses of LSD.
Changes in white matter fractional anisotropy (FA) were measured post-treatment, up to 12 weeks.
Correlation analysis was conducted between FA increases and symptom relief.
White matter fractional anisotropy (FA) significantly increased post-LSD treatment, particularly in regions associated with depression-related structural abnormalities.
Post-treatment FA increases correlated with symptom relief within 12 weeks, suggesting potential therapeutic effects.

Abstract

Moderate-to-high LSD doses increase white matter fractional anisotropy (FA) in MDD FA increases occur in regions linked to structural abnormalities in depression Post-treatment FA increases correlate with symptom relief up to 12 weeks

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