PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
May 10, 2026Nutrition and Health0 citations

trans -Chalcone protects against high-fat diet-induced kidney injury in rats by regulating the miR-874/TLR4 pathway

View Full Paper
EKElham Karimi‐SalesTabriz University of Medical SciencesKHKhalil HajiasgharzadehTabriz University of Medical SciencesMAMohammad Reza AlipourTabriz University of Medical Sciences

Key Points

  • The aim is to evaluate the protective effects of trans-chalcone against kidney injury caused by a high-fat diet via the miR-874/TLR4 pathway.
  • Administered trans-chalcone to rats on a high-fat diet to assess kidney protection.
  • Analyzed changes in the miR-874/TLR4 signaling pathway.
  • Trans-chalcone significantly reduced markers of kidney injury compared to control rats on a high-fat diet.
  • Regulated the expression of miR-874 and TLR4, indicating pathway involvement.

Abstract

-chalcone is a potential therapeutic chalcone for protecting the kidney against the dysregulation of the miR-874/TLR4 pathway during HFD feeding.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Karimi‐Sales et al. (2026) studied this question.

synapsesocial.com/papers/6a0020aec8f74e3340f9b759https://doi.org/10.1177/02601060261446821
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1High-fat emulsion-induced rat model of nonalcoholic steatohepatitis2006 · 235 citations
  2. 2Post-weaning Exposure to High-Fat Diet Induces Kidney Lipid Accumulation and Function Impairment in Adult Rats2019 · 49 citations
  3. 3miR-874-3p Is Identified as a Biomarker for Acute Kidney Injury and Mediates Disease Development via Targeting MSRB32023 · 9 citations
  4. 4TLR4 Signaling Mediates Inflammation and Tissue Injury in Nephrotoxicity2008 · 321 citations
  5. 5Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016–40 for 195 countries and territories2018 · 3,052 citations