Prospective trial evaluates local recurrence and survival rates post colorectal endoscopic dissection, suggesting low recurrence in curative cases.
Key Points
The objective was to evaluate long-term outcomes, specifically local recurrence rates and predictors, after colorectal endoscopic submucosal dissection (ESD).
Prospective multicenter study across 11 institutions in Hiroshima, Japan.
Included all consecutive colorectal ESD cases (1838 lesions from 1732 patients) between 2014 and 2018.
Analyzed local recurrence and survival using cause-specific Cox proportional hazards models.
Cumulative local recurrence rates were 0.06%, 0.64%, and 0.75% at 1, 3, and 5 years, respectively.
Rectal lesions and high-risk pathological features were significantly associated with local recurrence (HR, 3.93 and HR, 14.3, respectively).
5-year overall survival and cancer-specific survival rates were 95.3% and 100%, respectively.