Background: Baboon Syndrome, also known as symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), is a rare reaction characterised by distinct, bilateral erythema in the flexural and intertriginous regions, occurring without further symptoms. Case report: We present a 53-year-old gentleman who, three days after commencing diclofenac potassium for knee pain, exhibited symmetrical, well-defined erythema affecting the neck, axillae, cubital and popliteal fossae, forearms, inguinal folds, thighs, legs, and feet. He displayed no systemic symptoms or fever. The time and distinctive distribution of SDRIFE induced by diclofenac potassium were congruent. Management and Outcome: Following the cessation of diclofenac potassium, the patient received topical corticosteroids and oral antihistamines. The symptoms resolved after one week. In conclusion, this case highlights the necessity for physicians to identify this presentation for prompt diagnosis and care, and also indicates diclofenac potassium as a possible cause of SDRIFE. Keywords: Diclofenac potassium, Baboon Syndrome, SDRIFE, Flexural Erythema, Cutaneous Drug Eruption
AlKanderi et al. (2026) studied this question.