Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
May 10, 2026SLEEP

0056 State-Dependent Arousability to Noxious Stimuli During Sleep in Naïve and Nerve-Injured Mice

View Full Paper
Ask AI
Bookmark
Share

Authors

CAC AlexandreAGAllison GonzalezWHWilliam Hu

Discussion

Loading...

Member takes

Overview

Randomized trial evaluates sleep response to pain stimuli in nerve-injured mice, highlighting EEG dynamics and pain modulation.

Key Points

  • This study examines how pain affects sleep and the role of different sleep states in arousing from sleep due to pain.
  • Adult mice with channelrhodopsin-2 in pain-sensing neurons were monitored during NREM and REM sleep.
  • Calibrated optogenetic stimuli were delivered to assess awakening responses under various sleep conditions.
  • EEG/EMG data were analyzed to determine the likelihood of pain-evoked awakenings during different sleep states.
  • Pain-evoked awakenings occurred predominantly during NREM sleep (~90%), with minimal responses during REM sleep (<5%).
  • Higher sleep pressure and deeper NREM sleep moderately increased sleep maintenance despite nociceptive stimuli.
  • Pre-stimulus EEG showed increased delta and sigma power during NREM before nociceptive stimuli, affecting arousability.

Cite This Study

Alexandre et al. (2026) studied this question.

synapsesocial.com/papers/6a0020eac8f74e3340f9bc41https://doi.org/10.1093/sleep/zsag091.0056
View Full Paper
Ask AI
Bookmark
Share