Novel method demonstrates high-yield synthesis of γ-pyran derivatives using electron-deficient substrates, indicating new catalytic potential.
A novel phosphine-catalyzed [3+3] annulation of electron-deficient enyne-type propargylic carbonates with α-cyano ketones has been developed, giving tetrasubstituted γ-pyran derivatives in high yields. In this reaction, 1,2,3-butatriene phosphonium intermediates formed in situ acted as dielectrophilic reagents. This represents the first example of electron-deficient enyne-type propargylic carbonates being used as phosphine acceptors in phosphine catalysis.
No takes yet. Share an insight, caveat, or question.
Jin et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: