Comprehensive review of the cerebral aqueduct: anatomy, embryology, imaging, genetics, molecular, and pathology

Key Points

• This review aims to synthesize knowledge on the cerebral aqueduct's anatomy, molecular pathways, and surgical approaches related to congenital hydrocephalus.
• Conducted a literature review on the anatomy, embryology, imaging, and genetics of the cerebral aqueduct.
• Critically appraised surgical strategies such as endoscopic third ventriculostomy and aqueductoplasty.
• Evaluated efficacy, complications, and long-term outcomes of these interventions.
• Highlighted the role of mutations and molecular pathways in congenital hydrocephalus.
• Critically assessed surgical strategies revealing varying efficacy and complication profiles.
• Identified significant knowledge gaps in the understanding of the cerebral aqueduct's role.