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May 10, 2026European Journal of Organic Chemistry0 citations

Front Cover: Synthetic and Medicinal Chemistry Perspectives on Cereblon‐Binding Molecular Glue Degraders: Recent Advances and Emerging Trends (Eur. J. Org. Chem. 17/2026)

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HWHyuck‐Jae WonSBSeung Mok BaekMLMin Hoo Lee

Key Points

  • This review aims to highlight the recent advancements in CRBN-recruiting molecular glue degraders and their implications for medicinal chemistry.
  • Discussed recent advancements since 2023 in CRBN-recruiting molecular glue degraders.
  • Illustrated shift from canonical to non-canonical chemotypes.
  • Explained the role of AI-enabled modeling in accelerating the discovery process.
  • Identified new ligand-specific features that influence the CRBN–ligand–neosubstrate interface.
  • Demonstrated the expansion of neosubstrate space through recent discoveries.
  • Highlighted the potential impact of AI in facilitating the discovery of atypical molecular glue degraders.

Abstract

The Front Cover highlights advances in CRBN-recruiting molecular glue degraders since 2023, illustrating the shift from canonical glues to non-canonical chemotypes that expand the neosubstrate space. A glutarimide anchor binds to CRBN, while ligand-specific features shape the CRBN–ligand–neosubstrate interface. AI-enabled modeling can further accelerate the discovery of atypical MGDs. More information can be found in the Review by N.-J. Kim and co-workers (DOI: 10.1002/ejoc.202501208). Created in BioRender: Won, H.-J. (2026) https://BioRender.com/x39o4mt.

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Cite This Study

Won et al. (2026) studied this question.

synapsesocial.com/papers/6a00217ac8f74e3340f9c59dhttps://doi.org/10.1002/ejoc.70512
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