Abstract Introduction As cannabis legalization and availability expand, sleep-motivated cannabis use is increasing, yet little is known about how sleep-motivated cannabis use relates to cannabis use disorder (CUD) across race-ethnicity. This analysis aimed to examine patterns of sleep-related cannabis use and their association with CUD across two age-diverse cohorts in South Florida. Methods We utilized harmonized data from two ongoing cohort studies: Herbal Heart Study’s Sleep Ancillary Study (HSS; N=150; young adults) and the Canna-ESSENTIAL study (CE; N=60; middle-aged adults). Self-reported data on cannabis use were ascertained using the Sleep score of 12+) and hazardous use (score from 8-11). Chi-square and Fisher’s exact tests were conducted where appropriate. Results Of the total sample (N=210; Mage=30.4±10.9 years), 71.4% were young adults (Mage=25.6y), 28.6% middle-age adults (Mage=42.6y), 39.9% Non-Hispanic Black (NHB), 38.4% Hispanic, and 13.8% Non-Hispanic White (NHW). Over half (60.0%) of participants consumed cannabis in the past year, of which 39.3% of young adults and 15.0% of middle-aged adults were found to have CUD (p.0001). A majority of consumers (68.3%) reported consuming to improve their sleep quality, and 59.5% for duration. Among those consuming for sleep quality and/or duration, there were significant differences in CUDIT-R by race/ethnicity: 51.4% of NHB, 68.4% of Hispanics, and 44.4% of NHW with CUD. Likewise, hazardous cannabis use was observed among 44.4% of NHW, 5.7% of NHB, and 13.2% of Hispanic (p=0.008). Notably, 100.0% young adults reported consuming cannabis in the evening compared to 86.4% of middle-aged adults (p=0.01); and afternoon use was more common among Hispanics (65.8%) than among NHB (45.7%) or NHW participants (22.2%; p=0.04). Conclusion Cannabis use for sleep was frequent and associated with CUD and hazardous use, exhibiting racial-ethic differences. These results underscore the importance of CUD screening and culturally tailored harm-reduction education for sleep-related cannabis consumers. Support (if any) R01HL153467; T37MD008647; T32DA007292
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