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May 10, 2026Journal of NanobiotechnologyOpen Access

Self-propelled nanozyme motors for targeted therapy of radiation cystitis by disrupting the inflammation-cfDNA vicious cycle

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Authors

YHYongbiao HuangYZYang ZhongYYYuanmei Yan

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Overview

Randomized trial demonstrates targeted therapy for radiation cystitis, suggesting innovative treatment options.

Key Points

  • This study aims to develop a self-propelled nanozyme motor to clear cfDNA and restore redox balance in radiation cystitis.
  • Engineered a self-propelled nanozyme motor operational with endogenous urea.
  • Used intravesical instillation for medicinal delivery and sustained propulsion.
  • Conducted both in vitro and in vivo experiments to assess anti-inflammatory activity.
  • The nanozyme effectively reduced oxidative stress by eliminating reactive oxygen species.
  • Lowered activation of the cGAS-STING pathway and decreased pro-inflammatory cytokines release.
  • Demonstrated substantial mucosal coverage and deeper penetration in therapeutic application.

Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/6a0021b7c8f74e3340f9ca25https://doi.org/10.1186/s12951-026-04508-w
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