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May 10, 2026Chemical Science2 citationsOpen Access

Total and Engineered Biosynthesis of Cinatrins: Inhibitors of Phospholipase A2 and Squalene Synthase

HHHenrike HeinemannNGNick GerlachEKEric Kuhnert

Key Points

  • This research aims to identify and engineer a biosynthetic gene cluster from fungi that produces cinatrins, which inhibit phospholipase A2 and squalene synthase.
  • Identified alkyl citrate biosynthetic gene cluster (ctr) from 47 fungal genera through genome mining.
  • Utilized the Hypomontagnella monticulosa MUCL 54604 ctr cluster for biosynthesis of cinatrins.
  • Demonstrated successful identification of the ctr cluster in Hypoxylaceae fungi.
  • Showed that the produced cinatrins effectively inhibit phospholipase A2 and squalene synthase activities.

Abstract

An alkyl citrate biosynthetic gene cluster (ctr) was identified from 47 members of the fungal family of Hypoxylaceae by genome mining. The Hypomontagnella monticulosa MUCL 54604 ctr cluster was deployed...

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Cite This Study

Heinemann et al. (2026) studied this question.

synapsesocial.com/papers/6a0021fec8f74e3340f9ceb4https://doi.org/10.1039/d6sc00660d
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