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May 10, 2026SLEEP

0678 A Rare Case of Sodium Oxybates–Associated Central Sleep Apnea: First Known Use of Adaptive Servo Ventilation for Successful Therapy

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Authors

CWChristopher WilliamsAZAdel ZurobAZALI ZAIED

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Overview

Randomized trial demonstrates effective management of central sleep apnea in narcolepsy using adaptive servo ventilation.

Key Points

  • This research aims to explore the effective treatment of central sleep apnea associated with sodium oxybate using adaptive servo ventilation.
  • A 49-year-old woman with narcolepsy was treated with sodium oxybate and presented with central sleep apnea.
  • An in-lab polysomnogram confirmed moderate central sleep apnea, prompting adaptive servo ventilation as management.
  • The patient underwent adaptive servo ventilation titration while continuing sodium oxybate therapy.
  • Patient tolerated adaptive servo ventilation well, achieving a residual AHI of 4.6 events per hour.
  • Adherence to adaptive servo ventilation exceeded 93% with more than four hours of nightly use.
  • Significant improvement in daytime alertness was observed while continuing sodium oxybate without respiratory complications.

Cite This Study

Williams et al. (2026) studied this question.

synapsesocial.com/papers/6a002222c8f74e3340f9d166https://doi.org/10.1093/sleep/zsag091.0677
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