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January 25, 2013American Journal of Respiratory and Critical Care MedicineOpen Access

Characteristics of Lung Cancers Detected by Computer Tomography Screening in the Randomized NELSON Trial

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Key Points

To assess how stringent referral criteria and increasing screening intervals influence the stage distribution, histology, and localization of screen-detected lung cancers across screening rounds and sexes.
Study (ISRCTN63545820; N=15,822) evaluating a volumetry-based low-dose CT screening strategy characterized by strict referral thresholds and lengthening screening intervals.
Evaluated all participants diagnosed with screen-detected lung cancer across the first three screening rounds, comparing cancer stage, histology, and tumor location between rounds, sexes, and external trials.
Across three rounds, 200 participants were diagnosed with 209 lung cancers; 70.8% were stage I, 8.1% were stage IIIB-IV, and 51.2% were adenocarcinomas.
Cancer stage, histology, and tumor location did not differ significantly across screening rounds, but women presented with significantly more favorable cancer stages than men.
Screen-detected lung cancers showed higher proportions of stage I and lower proportions of stage IIIB-IV disease compared with results from other lung cancer screening trials.

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Implication

Demonstrates high early-stage lung cancer detection in screened participants, indicating screening effectiveness despite strict referral criteria.

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Cite This Study

Horeweg et al. (2013) studied this question.

synapsesocial.com/papers/6a0023076018b8d0892dabba https://doi.org/10.1164/rccm.201209-1651oc

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