Ultrahigh-yield synthesis of N-doped carbon nanodots that down-regulate ROS in zebrafish

, where conjugated π-systems as electron donors and pyridinic-like structures would benefit the potential down-regulated effect for ROS. N-doped CNDs exhibit an outstanding protective effect against oxidative stress via inhibiting exogenous and endogenous ROS generation, where the ROS in zebrafish are significantly reduced by 68%. Hence the concept of carbon-carbon double bond-boosted ultrahigh-yield synthesis of N-doped CNDs provides a promising strategy to be employed for carbonaceous nanodrugs aiming at preventing and curing ageing and age-related diseases.