Quick UDP Internet Connection (QUIC) is a recent protocol initiated by Google that combines the functions of HTTP/2, TLS, and TCP directly over UDP, with the goal to reduce the latency of client-server communication. It can replace the traditional HTTP/TLS/TCP stack and the IETF has chartered a working group to standardize it. QUIC encrypts all data and most protocol headers to prevent interferences from middleboxes.
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Coninck et al. (2017) studied this question.
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