Key points are not available for this paper at this time.
-ATPase functioning, where below cell volume rapidly increases as a function of the remaining pump activity, and a Gibbs-Donnan-like equilibrium state is reached. This precludes a return to physiological conditions even when pump strength returns to baseline. However, when voltage-gated sodium channels are temporarily blocked, cell volume and membrane potential normalize, yielding a potential therapeutic strategy. SIGNIFICANCE STATEMENT: channels.
Dijkstra et al. (Wed,) studied this question.