January 13, 2011AJP Cell Physiology

Protective cross talk between activated protein C and TNF signaling in vascular endothelial cells: implication of EPCR, noncanonical NF-κB, and ERK1/2 MAP kinases

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Why the study?

Does activated protein C attenuate inflammation and impair TNF signaling in vascular endothelial cells?

Population

Vascular human endothelial cells (EC)

Design

Preclinical

Authors

CGChristophe GuittonStar Technology and Research (United States)ACAlice CottereauCentre Hospitalier Intercommunal André Grégoire Montreuil NGNathalie GérardInserm

Discussion

Member takes

Implication

Supports APC endothelial protection in animals; leaves open human translation and clinical relevance.

Structured PICO

Does activated protein C attenuate inflammation and impair TNF signaling in vascular endothelial cells?

Population

Vascular human endothelial cells (EC)

Intervention

Activated protein C (APC)

Outcome

Modulation of cell adhesion molecules (CAMs) including VCAM-1 and signaling pathways (NF-κB, ERK1/2, Akt) in response to TNFsurrogate

Activated protein C exerts protective anti-inflammatory effects in vascular endothelial cells by engaging EPCR, ERK, and NF-κB pathways to impair TNF signaling.

Cite This Study

Guitton et al. (2011) studied this question.

synapsesocial.com/papers/6a006612da5c1eb07f2da719 https://doi.org/10.1152/ajpcell.00003.2010

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Protective cross talk between activated protein C and TNF signaling in vascular endothelial cells: implication of EPCR, noncanonical NF-κB, and ERK1/2 MAP kinases

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Protective cross talk between activated protein C and TNF signaling in vascular endothelial cells: implication of EPCR, noncanonical NF-κB, and ERK1/2 MAP kinases

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider