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March 13, 2020Gut648 citationsOpen Access

A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8 + T cells in mice

LWLijuan WangLTLei TangYFYiming Feng

Key Points

  • This research aims to explore the immune response related to colitis-associated tumorigenesis (CAC) and the role of the purified Akkermansia muciniphila protein.
  • Investigated the effect of the purified membrane protein Amuc_1100 on immune response during acute colitis and CAC in mice.
  • Analyzed CTL activation in colon and MLN based on TNF-α induction and PD-1 downregulation.
  • Amuc_1100 blunted tumourigenesis by expanding cytotoxic T lymphocytes (CTLs) in the colon and MLN.
  • Activation of CTLs was indicated by TNF-α induction and downregulation of PD-1, demonstrating immune response modulation.

Abstract

OBJECTIVE: engages the immune response in CAC. DESIGN: or Amuc₁100 on the immune response in acute colitis and CAC were investigated. RESULTS: and Amuc₁100 blunted tumourigenesis by expanding CTLs in the colon and MLN. Remarkably, they activated CTLs in the MLN, as indicated by TNF-α induction and PD-1downregulation. Amuc₁100 could stimulate and activate CTLs from splenocytes in CT26 cell conditioned medium. CONCLUSIONS: or Amuc₁100 can blunt colitis and CAC through the modulation of CTLs.

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Cite This Study

Wang et al. (2020) studied this question.

synapsesocial.com/papers/6a006a7eda5c1eb07f2da8dfhttps://doi.org/10.1136/gutjnl-2019-320105
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