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January 1, 2001Korean Journal of Parasitology549 citationsOpen Access

Highlights of human toxocariasis

JMJean‐François MagnavalLGLawrence T. GlickmanPDPhilippe Dorchies

Key Points

  • To summarize the epidemiology, transmission pathways, diagnostic strategies, clinical syndromes, and therapeutic management of human toxocariasis.
  • Reviewed transmission mechanisms involving ingestion of embryonated Toxocara eggs from soil, food, or undercooked animal tissues.
  • Assessed diagnostic immunological assays targeting excretory-secretory antigens and compared clinical management across syndrome presentations.
  • Identified four distinct clinical presentations: visceral larva migrans, ocular larva migrans, adult common toxocariasis, and pediatric covert toxocariasis.
  • Established that ocular disease primarily requires corticosteroid therapy, whereas visceral and covert cases respond effectively to anthelmintics including diethylcarbamazine.
  • Reported elevated seroprevalence across rural developed regions and tropical islands, emphasizing mandatory pet deworming and sanitary education for prevention.

Abstract

Human toxocariasis is a helminthozoonosis due to the migration of Toxocara species larvae through human organism. Humans become infected by ingesting either embryonated eggs from soil (geophagia, pica), dirty hands or raw vegetables, or larvae from undercooked giblets. The diagnosis relies upon sensitive immunological methods (ELISA or western-blot) which use Toxocara excretory-secretory antigens. Seroprevalence is high in developed countries, especially in rural areas, and also in some tropical islands. The clinical spectrum of the disease comprises four syndromes, namely visceral larva migrans, ocular larva migrans, and the more recently recognized "common" (in adults) and "covert" (in children) pictures. Therapy of ocular toxocariasis is primarily based upon corticosteroids use, when visceral larva migrans and few cases of common or covert toxocariasis can be treated by anthelmintics whose the most efficient appeared to be diethylcarbamazine. When diagnosed, all of these syndromes require thorough prevention of recontamination (especially by deworming pets) and sanitary education.

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Cite This Study

Magnaval et al. (2001) studied this question.

synapsesocial.com/papers/6a0078ab413f0c047f2d7807https://doi.org/10.3347/kjp.2001.39.1.1
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