The Inter-Organ Crosstalk Reveals an Inevitable Link between MAFLD and Extrahepatic Diseases

Figures

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  Figure 1. Flowchart of criteria for MAFLD proposed by the global expert consensus panel. Abbreviations: MAFLD, metabolic abnormality-associated fatty liver disease. Adapted with permission from Ref. [7], 2020, Eslam et al.

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  Figure 2. Major differences between MAFLD and NAFLD are based on metabolic abnormalities and alcohol consumption. Abbreviations: MAFLD, metabolic abnormality-associated fatty liver disease. Adapted with permission from Ref. [11], 2022, Kawaguchi et al.

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  Figure 3. Major pathological mechanisms of multiorgan carcinogenesis. The dotted line indicates features of MAFLD. Abbreviations: MAFLD, metabolic abnormality-associated fatty liver disease; CAA, cancer-associated adipocytes; CLS, crown-like structures.

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  Figure 4. The relationships between MAFLD and multiorgan disease. Abbreviations: MAFLD, metabolic abnormality-associated fatty liver disease; ASCVD, atherosclerotic cardiovascular disease; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; OSAS, obstructive sleep apnea syndrome; PCOS, polycystic ovary syndrome; IBD, inflammatory bowel disease; HCC, hepatocellular carcinoma.