Key result
Natriuretic peptides correlate with disease severity, symptoms, and outcomes in aortic and mitral valve disease.
Why the study?
Management of asymptomatic patients with common valvular heart disease remains controversial, and the clinical impact of natriuretic peptide measurement needs further assessment.
Do natriuretic peptides have utility as biomarkers for assessing disease severity and predicting outcomes in patients with aortic stenosis and mitral regurgitation?
Do natriuretic peptides have utility as biomarkers for assessing disease severity and predicting outcomes in patients with aortic stenosis and mitral regurgitation?
Natriuretic peptides show promise as biomarkers for assessing disease severity and predicting outcomes in aortic stenosis and mitral regurgitation, though prospective studies are needed to establish their role in routine clinical practice.
Valvular heart disease, particularly aortic stenosis and mitral regurgitation, accounts for a large proportion of cardiology practice, and their prevalence is predicted to increase. Management of the asymptomatic patient remains controversial. Biomarkers have been shown to have utility in the management of cardiovascular disease such as heart failure and acute coronary syndromes. In this state-of-the-art review, we examine the current evidence relating to natriuretic peptides as potential biomarkers in aortic stenosis and mitral regurgitation. The natriuretic peptides correlate with measures of disease severity and symptomatic status and also can be used to predict outcome. This review shows that natriuretic peptides have much promise as biomarkers in common valvular heart disease, but the impact of their measurement on clinical practice and outcomes needs to be further assessed in prospective studies before routine clinical use becomes a reality.
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Steadman et al. (2010) conducted a review in Valvular heart disease (aortic stenosis and mitral regurgitation). Natriuretic peptides was evaluated. Natriuretic peptides correlate with disease severity, symptomatic status, and outcomes in aortic stenosis and mitral regurgitation, showing promise as clinical biomarkers.
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