What is the clinical evidence from this study?

Study design: Cohort. Population: Peripheral arterial disease (n=229). Intervention: Tibial artery calcification vs. Lower tibial artery calcification score. Primary outcome: Major amputation.

What question did this study set out to answer?

To evaluate the relationship between tibial artery calcification, the severity of limb ischemia, and the near-term risk of amputation in patients with peripheral arterial disease.

May 10, 2026Journal of the American College of CardiologyOpen Access

Tibial Artery Calcification as a Marker of Amputation Risk in Patients With Peripheral Arterial Disease

View Full Paper

Ask AI

Bookmark

Key result

Tibial artery calcification score >400 is strongly linked to higher near-term major amputation risk in PAD.

n=229

Why the study?

Determining amputation risk in patients with peripheral arterial disease remains difficult, necessitating new measures to identify high-risk patients for targeted interventions.

Does tibial artery calcification score predict near-term amputation risk better than ABI in patients with peripheral arterial disease?

Population

229 patients with peripheral arterial disease evaluated by history, arterial Doppler, and multi-slice CT

Comparison

Tibial artery calcification score vs ankle-brachial index and traditional risk factors

Design

Cohort study

Authors

RGRaul J. GuzmanJoslin Diabetes Center DBD. Marshall BrinkleyVanderbilt University PSPaul M. SchumacherUniversity of Central Florida

Discussion

Member takes

Implication

Tibial artery calcification score is a strong predictor of near-term major amputation risk in patients with PAD, outperforming traditional risk factors and ABI.

Key Points

To evaluate the relationship between tibial artery calcification, the severity of limb ischemia, and the near-term risk of amputation in patients with peripheral arterial disease.
Evaluated 229 patients with peripheral arterial disease using clinical history, arterial Doppler ultrasound, and lower-extremity multi-slice computed tomography.
Quantified tibial artery calcification (TAC) scores alongside traditional cardiovascular risk factors and ankle-brachial index (ABI) measurements.
Assessed associations with limb ischemia severity and near-term amputation risk using ordinal regression, receiver operating characteristic analysis, and multivariable Cox proportional hazards regression.
Tibial artery calcification scores increased with age and traditional risk factors, with the highest scores observed in patients with critical limb ischemia.
Receiver operating characteristic analysis indicated that the TAC score predicted amputation better than ABI, with symptomatic patients with a TAC score greater than 400 facing a significantly higher risk of amputation.
Multivariable Cox regression analysis showed a strong association between elevated TAC scores and major amputation that remained significant after adjusting for ABI and traditional risk factors.

Study Design

Type

Cohort (n=229)

Structured PICO

Does tibial artery calcification score predict near-term amputation risk better than ABI in patients with peripheral arterial disease?

Population

229 patients with peripheral arterial disease evaluated to determine the relationship between tibial artery calcification and near-term amputation risk.

Exposure

Tibial artery calcification (TAC) score assessment via multi-slice CT

Comparator

Ankle-Brachial Index (ABI) and traditional risk factors

Outcome

Near-term risk of major amputationhard clinical

Tibial artery calcification score is a strong predictor of near-term major amputation risk in patients with PAD, outperforming traditional risk factors and ABI.

Cite This Study

Guzman et al. (2008) conducted a cohort in Peripheral arterial disease (n=229). Tibial artery calcification vs. Lower tibial artery calcification score was evaluated on Major amputation. A tibial artery calcification score greater than 400 was strongly associated with an increased near-term risk of major amputation in patients with peripheral arterial disease.

synapsesocial.com/papers/6a00a1e6c7e433e6e73f3c17 https://doi.org/10.1016/j.jacc.2007.12.058

View Full Paper

Ask AI

Bookmark

Implication

Tibial artery calcification score is a strong predictor of near-term major amputation risk in patients with PAD, outperforming traditional risk factors and ABI.

Tibial Artery Calcification as a Marker of Amputation Risk in Patients With Peripheral Arterial Disease

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Tibial Artery Calcification as a Marker of Amputation Risk in Patients With Peripheral Arterial Disease

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider