Why the study?
Does baroreceptor deafferentation alter the cardiovascular responses to hyperbaric oxygen in rats?
Population
Anesthetized and conscious rats after deafferentation of aortic or carotid baroreceptors or both
Comparison
Hyperbaric oxygen at 2.5 ATA for conscious rats… vs Intact animals exposed to the same HBO2 conditions
Design
Preclinical
Authors
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Supports baroreflex mediation of hyperbaric oxygen effects in rats; leaves open translation to human hyperbaric therapy.
Does baroreceptor deafferentation alter the cardiovascular responses to hyperbaric oxygen in rats?
The initial cardiovascular responses to moderate levels of hyperbaric oxygen (hypertension, bradycardia, reduced CO) are coordinated through a baroreflex-mediated mechanism initiated by HBO2-induced vasoconstriction.
It et al. (2013) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: