Is increased carotid intima-media thickness associated with symptomatic and asymptomatic peripheral arterial disease in older adults?
Small increases in carotid intima-media thickness are significantly associated with both symptomatic and asymptomatic peripheral arterial disease in older adults.
BACKGROUND AND PURPOSE: Ultrasonic evaluation of intimamedia thickness (IMT) is one method of assessing the development of early atherosclerosis. This report describes the distribution of IMT within the general population and is one of the first to investigate its association with noninvasively assessed symptomatic and asymptomatic peripheral arterial disease. METHODS: Ultrasonic evaluation of IMT was included in the 5-year follow-up examination of participants of the Edinburgh Artery Study. Valid readings of IMT were recorded in 1106 subjects aged 60 to 80 years, and the maximum from the right and left sides of the neck was used in the analysis. Existing symptomatic and asymptomatic peripheral arterial disease and coronary heart disease were also assessed at follow-up using previously validated noninvasive techniques. RESULTS: IMT increased continuously with age (P 2 mm). The presence of symptomatic (intermittent claudication) or asymptomatic (ankle brachial pressure index < or = 0.9) peripheral arterial disease was significantly associated with increased IMT (P < or = .05). CONCLUSIONS: Although the prevalence of advanced atherosclerosis was very low, small changes in IMT were associated with clinically significant development of atherosclerosis in the peripheral arteries. However, further longitudinal studies are needed that standardize measurement techniques and would allow accurate comparisons across studies.
Allan et al. (Sat,) studied this question.