Fractional CO2 lasers contribute to the treatment of stable non-segmental vitiligo

BACKGROUND: Stable non-segmental vitiligo is often resistant to conventional therapies. OBJECTIVES: The purpose of this study was to investigate the effect of three types of fractional lasers in the treatment of stable non-segmental vitiligo. MATERIALS & METHODS: lasers and one non-ablative 1,565-nm laser), followed by topical betamethasone solution application. The treatment period lasted six months. Efficacy and satisfaction were respectively assessed by dermatologists and patients. RESULTS: lasers, in combination with topical betamethasone solution and NB-UVB, achieved marked to excellent improvement on white patches assessed by dermatologists. Patients showed high satisfaction scores for the treatments. The non-ablative 1,565-nm fractional laser did not provide any further benefit in the treatment of vitiligo. No severe adverse events developed for any of the treatments. CONCLUSION: laser is more effective than the non-ablative fractional laser.