EFFECTIVE MICROWAVE SYNTHESIS OF BIOACTIVE THIENO[2,3-d]PYRTMIDINES

A series of novel 2-amino-3-cyanothiophenes (2a-2j) were synthesized using heterogeneous base (K 2 CO 3 ) supported Gewald reaction. Cyclization of 2a-j with formamide and urea in conventional heating as well as microwave irradiation gave thieno [2,3-d]pyrimidines (3a-3j) and thieno [2,3-d]pyrimidin-2(1H)ones(4a-4j) respectively. The reaction rates were faster and yields were higher in the microwave conditions. The structures of the compounds were confirmed with elemental analysis, mass spectral analysis, FTIR, 1 H NMR and 13 C NMR techniques. All the synthesized compounds were subjected to antimicrobial activity (MIC) in vitro by broth dilution method and exhibited a moderate antimicrobial activity.