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The first clear, recognizably scientific representations of the human brain were the and engravings of the Renaissance anatomists. These prototype anatomical of brain organization demonstrated a physical structure somewhat -like in appearance: an approximately symmetrical pair of deeply wrinkled connected to each other by a central bridge of tissue. More extensive detailed dissection of the human brain revealed that its convoluted surface thinly covered (less than 3 mm) by a layer of so-called grey matter— cortex; and that anatomically separated regions of cortical grey matter are interconnected to each other (and to subcortical grey matter nuclei) axonal projections that are bundled together to form macroscopically visible matter tracts, including the major white matter tract linking the two hemispheres.
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Papo et al. (2014) studied this question.
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