May 23, 2018Journal of Clinical Oncology139 citationsOpen Access

Cardiac Structure Injury After Radiotherapy for Breast Cancer: Cross-Sectional Study With Individual Patient Data

CTCarolyn TaylorCardiac Imaging PMPaul McGaleCardio-Oncology DBDorthe BrønnumChinese Academy of Medical Sciences & Peking Union Medical College

Structured PICO

Are higher radiation doses associated with more frequent cardiac structure injury in breast cancer patients?

Population

Patients with breast cancer who received radiotherapy

Intervention

Higher radiation doses

Comparator

Lower radiation doses

Outcome

Cardiac structure injury (LV and coronary artery segments)surrogate

Higher radiation doses to individual LV and coronary artery segments during breast cancer radiotherapy are associated with more frequent cardiac injury, highlighting the need to minimize doses to all segments.

Abstract

= .002). Conclusion For individual LV and coronary artery segments, higher radiation doses were strongly associated with more frequent injury, suggesting that all segments are sensitive to radiation and that doses to all segments should be minimized.

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