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April 8, 2021Journal of Medicinal ChemistryOpen Access

Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion

Zenon Konteatis Jeremy Travins Stefan Größ Katya Marjon Amelia Barnett Everton Mandley Brandon Nicolay Raj Nagaraja Yue Chen Yabo Sun Zhixiao Liu Jie Yu Zhixiong Ye Fan Jiang Wentao Wei Fang Cheng Yi Gao Peter Kalev Marc L. Hyer Byron DeLaBarre Lei Jin Anil K. Padyana Lenny Dang Joshua Murtie Scott A. Biller Zhihua Sui Kevin M. Marks

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into current clinical studies (ClinicalTrials.gov NCT03435250).

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Konteatis et al. (2021) studied this question.

synapsesocial.com/papers/6a00d768e4618ba4162dc18c https://doi.org/10.1021/acs.jmedchem.0c01895

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Amplified and Homozygously Deleted Genes in Glioblastoma: Impact on Gene Expression LevelsOriginal Research · 2012 · 46 citations
2MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 AxisOriginal Research · 2016 · 428 citations
3Concordant Loss of MTAP and p16/CDKN2A Expression in Gastroesophageal CarcinogenesisOriginal Research · 2005 · 60 citations
4<i>MTAP</i> deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cellsOriginal Research · 2016 · 666 citations
5Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5Original Research · 2016 · 605 citations

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