Why the study?
Does disopyramide affect sinus node automaticity and atrioventricular conduction?
Does disopyramide affect sinus node automaticity and atrioventricular conduction?
Disopyramide exerts direct depressant effects on sinus node and AV conduction that can be masked by its anticholinergic properties in vivo.
Direct depressant effects warrant caution in patients with sinus/AV node dysfunction; leaves open net in vivo impact.
Disopyramide has been shown in conditions of cholinergic blockade to have a depressant effect upon sinus node automaticity and the atrial refractoriness. It also prolongs atrioventricular conduction and increases atrioventricular refractoriness. These effects may often be masked in vivo by the anticholinergic effects of the drug.
No takes yet. Share an insight, caveat, or question.
Birkhead et al. (1977) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: