Why the study?
Does postnatal enalapril improve echocardiographic measurements in women following preterm preeclampsia?
Does postnatal enalapril improve echocardiographic measurements in women following preterm preeclampsia?
Postnatal enalapril is feasible, acceptable, and associated with early improvements in echocardiographic measurements at 6 months in women following preterm preeclampsia.
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Supports postnatal enalapril for cardiac recovery after preterm preeclampsia; extends RCT evidence to this population.
=0.03) at 6 months, compared with placebo. Urinary enalapril was detectable in 85% and 63% of women in the enalapril arm at 6 weeks and 6 months, respectively. All women responded positively to taking enalapril in the future. Our study confirmed acceptability and feasibility of the study protocol with a recruitment to completion rate of 2.2 women per month. Importantly, postnatal enalapril treatment was associated with improved echocardiographic measurements; these early improvements have the potential to reduce long-term cardiovascular disease risk. A definitive, multicenter randomized controlled trial is now required to confirm these findings. Registration- URL: https://www.clinicaltrials.gov; Unique identifier: NCT03466333.
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Ormesher et al. (2020) studied this question.
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