Myosin-V is a tightly coupled motor whose cycle time is limited by ADP release, providing a molecular model for its processivity.
Animal data on myosin-V kinetics warrant no clinical change; leaves open human cardiac translation.
Myosin-V is a molecular motor that moves processively along its actin track. We have used a feedback-enhanced optical trap to examine the stepping kinetics of this movement. By analyzing the distribution of time periods separating discrete approximately 36-nm mechanical steps, we characterize the number and duration of rate-limiting biochemical transitions preceding each such step. These data show that myosin-V is a tightly coupled motor whose cycle time is limited by ADP release. On the basis of these results, we propose a model for myosin-V processivity.
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Rief et al. (2000) studied this question.
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