Recent Progress in Physiological Significance and Biosynthesis of Lacto-N-triose II: Insights into a Crucial Biomolecule

Cuie Guang; Zhihui Du; Jiawei Meng; Yunqi Zhu; Yingying Zhu; Wanmeng Mu

doi:10.1021/acs.jafc.4c04284

August 27, 2024Journal of Agricultural and Food Chemistry

Recent Progress in Physiological Significance and Biosynthesis of Lacto-N-triose II: Insights into a Crucial Biomolecule

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Key Points

Summarize the physiological functions, structural characteristics, and biotechnological production routes of lacto-N-triose II (LNTri II).
Synthesized evidence on enzymatic pathways of LNTri II involving acetylglucosaminyltransferases.
Evaluated metabolic engineering approaches and engineered microbial host platforms developed for large-scale biosynthesizing of LNTri II.
Documented microbial cell factory platforms and pathway optimization strategies enabling efficient and scalable LNTri II bioproduction.
Characterized the molecular structure, key chemical derivatives, and physiological activities associated with LNTri II.

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Implication

Narrative review highlights metabolic engineering and physiological roles of lacto-N-triose II, suggesting scalable cell factory platforms for human health applications.

Abstract

-acetylglucosaminyltransferases. Additionally, metabolic engineering and cell factory approaches have been explored, harnessing the potential of engineered microbial hosts for the large-scale biosynthesis of LNTri II. This review summarizes the structure, derivatives, physiological effects, and biosynthesis of LNTri II.

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Guang et al. (2024) studied this question.

synapsesocial.com/papers/6a011dd72ff633f365783bf9 https://doi.org/10.1021/acs.jafc.4c04284

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Recent Progress in Physiological Significance and Biosynthesis of Lacto-N-triose II: Insights into a Crucial Biomolecule

Key Points

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Implication

Abstract

Discussion

Cite This Study

Recent Progress in Physiological Significance and Biosynthesis of Lacto-N-triose II: Insights into a Crucial Biomolecule

Key Points

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Implication

Abstract

Discussion

Cite This Study

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