Characterization of CD45RO+ memory T lymphocytes in keloid disease

BACKGROUND: Memory T cells, a highly effective subset of T lymphocytes, have been reported to be involved in many inflammatory skin disorders. However, the potential role of memory T cells in keloid disease (KD) remains unclear. OBJECTIVES: memory T cells in KD. METHODS: Primary cutaneous cells were isolated from keloid scars and normal skin by enzymic digestion. Peripheral blood mononuclear cells were isolated from a related blood sample, and flow cytometry was applied to identify the phenotypic and functional abnormalities of memory T cells in KD. RESULTS: memory T cells in keloid scars. CONCLUSIONS: memory T cells in keloid scars and provide early evidence that a disrupted T-cell response contributes to the progression of KD.