Discovery of a Tetrazole-Based Growth Hormone Secretagogue:  4-(Hydroxybutyl)carbamic Acid 2-{5-[1-(2-Amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl Ester (BMS-317180)

Jun Li; Stephanie Chen; James J. Li; Haixia Wang; Andrés S. Hernández; Shiwei Tao; Christa M. Musial; Fucheng Qu; Stephen G. Swartz; Sam Chao; Neil Flynn; Brian J. Murphy; Dorothy Slusarchyk; Ramakrishna Seethala; Mujing Yan; Paul G. Sleph; Gary J. Grover; Mark A. Smith; Blake C. Beehler; Leah Giupponi; Kenneth E.J. Dickinson; Hongjian Zhang; W. Griffith Humphreys; Bharat Patel; Mark D. Schwinden; Terry R. Stouch; Peter T. W. Cheng; Scott A. Biller; William R. Ewing; David Gordon; Jeffrey A. Robl; Joseph A. Tino

doi:10.1021/jm7010595

Abstract

A tetrazole-based peptidomimetic 2 (BMS-317180) was discovered as a human growth hormone secretagogue (GHS). Compound 2 is a potent, novel, orally effective GHS that shows an excellent safety profile in preclinical studies. The compound was advanced into clinical development.

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Li et al. (2007) studied this question.

synapsesocial.com/papers/6a0130c7581c6e761e77fea4 https://doi.org/10.1021/jm7010595

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Discovery of a Tetrazole-Based Growth Hormone Secretagogue: 4-(Hydroxybutyl)carbamic Acid 2-{5-[1-(2-Amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl Ester (BMS-317180)

Abstract

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Cite This Study

Discovery of a Tetrazole-Based Growth Hormone Secretagogue: 4-(Hydroxybutyl)carbamic Acid 2-{5-[1-(2-Amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl Ester (BMS-317180)

Abstract

Discussion

Cite This Study

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