Carborane‐Based Carbonic Anhydrase Inhibitors

Humane Carboanhydrasen (CAs) werden diagnostisch und therapeutisch genutzt. Verschiedene Carborane wirken hemmend auf die aktiven Zentren von CAs, wobei die Einführung einer Sulfamidgruppe und anderer Substituenten zu Verbindungen mit hoher Selektivität für das krebsspezifische Isozym IX führt. Kristallstrukturen mit den Carboranen im aktiven Zentrum liefern Informationen für das strukturbasierte Design spezifischer Inhibitoren. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.