Key result
Plaque neovasculature shows ~2-fold higher adhesion molecule expression than luminal endothelium, linked to leukocyte infiltration.
Why the study?
No previous study has evaluated the distribution of E-selectin, ICAM-1, and VCAM-1 at different sites within the arterial intima or their relation to plaque leukocyte content in human atherosclerosis.
Cross-Sectional (n=99)
p-value: p=<.01
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May implicate neovascular endothelium in plaque inflammation; hypothesis-generating for adhesion-targeted therapies.
O’Brien et al. (1996) conducted a cross-sectional in Atherosclerosis (n=99). Atherosclerotic plaque vs. Control coronary artery segments was evaluated on Prevalence of E-selectin, ICAM-1, and VCAM-1 on plaque neovasculature and association with intimal macrophage and T-lymphocyte density (p=<.01). In atherosclerotic plaques, E-selectin, ICAM-1, and VCAM-1 expression was twofold higher on intimal neovasculature than on arterial luminal endothelium and associated with increased leukocyte density (P<0.01).
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