Relationship of Serum Digoxin Concentration to Mortality and Morbidity in Women in the Digitalis Investigation Group Trial

“A post-hoc analysis of the DIG trial by Rathore and associates showed that digoxin was associated with a significantly higher risk of death among women (HR 1.23; CI, 1.02 to 1.47), but not men (HR 0.93; CI 0.85 to 1.02; P=0.014 for the interaction). The authors suggested that their results may be due to gender-associated differences in the pharmacokinetics of digoxin, which would suggest that lower dosing may be required for women to maintain an optimal SDC.”