Answers are grounded in this paper and cite their sources.
A modular, 18-step total synthesis of hyperforin is described. The natural product was quickly accessed using latent symmetry elements, whereby a group-selective, Lewis acid-catalyzed epoxide-opening cascade cyclization was used to furnish the bicyclo[3.3.1]nonane core and set two key quaternary stereocenters.
No takes yet. Share an insight, caveat, or question.
Sparling et al. (2012) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: