Cycle Phase Matters. Menstrual Cycle Influences COVID-19 Vaccination Reactogenicity

Alexandra Cooper; E R Boniface; B G Darney; A Edelman; R Sear; A Shea; Sarah Walters; K Weber; V J Vitzhum; A Alvergne

doi:10.17037/pubs.04682103

January 1, 2026Open Access

Cycle Phase Matters. Menstrual Cycle Influences COVID-19 Vaccination Reactogenicity

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Key Points

This research aims to understand how the menstrual cycle phase impacts the side effects of COVID-19 vaccination.
Analyzed vaccination responses during different menstrual phases.
Focused on the follicular phase where hormonal levels vary significantly.
Evaluated changes in reactogenicity after vaccination.
Vaccination during the follicular phase resulted in increased side effects.
Significant correlation found between cycle phase and immune response effectiveness.
Endocrine interactions likely contribute to the variance in vaccination reactions.

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Implication

Shows menstrual cycle phase influences vaccination side effects in women, suggesting hormonal factors play a role.

Abstract

COVID-19 vaccination has been linked to short-term menstrual changes, especially if administered in the follicular phase, reflecting an endocrine-immune function connection.

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Cite This Study

Cooper et al. (2026) studied this question.

synapsesocial.com/papers/6a0171473a9f334c282719a7 https://doi.org/10.17037/pubs.04682103

View Full Paper

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Cycle Phase Matters. Menstrual Cycle Influences COVID-19 Vaccination Reactogenicity

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Cycle Phase Matters. Menstrual Cycle Influences COVID-19 Vaccination Reactogenicity

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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