Electrochemical sensor for detection of neurotransmitter serotonin using platinum nanoparticle modified electrode

Impaired 5-HT function can lead to clinical depression, which is one of the most serious problems nowadays and the number of people suffering from it is growing worldwide.Given the (patho)physiological importance of serotonin, its analysis is necessary.It plays a major role in both neurological and metabolic diseases.In this research, a platinum wire modified with platinum nanoparticles (PtNPs) was used to detect serotonin.The structural and morphological characteristics of the electrode were extensively investigated using scanning electron microscopy (SEM).To characterize the electrochemical performance of the electrodes (before and after surface modification) cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) was employed.The CV results demonstrated that incorporating PtNPs significantly increased the current response of 5-HT and impedance studies revealed that charge transfer resistance decreases.Hence, the designed electrodes have potential applications in in-vivo neurotransmitter detection in future studies.