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May 11, 2026Genes & DiseasesOpen Access

Research advances of disulfidptosis in inflammatory diseases

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Authors

YMYizhao MaTongji UniversityXYXingpeng YangChinese PLA General HospitalYBYi BaoNankai University

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Implication

Review delineates molecular mechanisms and therapeutic strategies for disulfidptosis in inflammatory diseases, indicating significant implications.

Key Points

  • This review explores the role of disulfidptosis in inflammatory diseases and its distinct mechanisms.
  • Systematic review of molecular mechanisms of disulfidptosis and its distinction from classical regulated cell death
  • Analysis of specific inflammatory conditions such as sepsis, osteoarthritis, and ulcerative colitis
  • Evaluation of therapeutic strategies targeting SLC7A11, Rac pathway, and cytoskeletal stability.
  • Disulfidptosis is induced by disulfide stress and involves cysteine metabolic imbalance and NADPH depletion
  • There is significant pathophysiological contribution of disulfidptosis to inflammatory disorders
  • Controversies exist regarding its distinctness as a regulated cell death entity and its interactions with other cell death modalities.

Cite This Study

Ma et al. (2026) studied this question.

synapsesocial.com/papers/6a01720a3a9f334c2827218fhttps://doi.org/10.1016/j.gendis.2026.102227
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