What question did this study set out to answer?

This study aims to explore changes in basal forebrain connectivity and glucose metabolism in Alzheimer's disease and their relationship with neurotransmitter distributions.

May 11, 2026CNS Neuroscience & TherapeuticsOpen Access

Correspondence of Basal Forebrain Resting‐State Functional Connectivity and Cerebral Glucose Metabolism Alterations With Neurotransmitter Maps in Alzheimer's Disease

View Full Paper

Ask AI

Bookmark

This study aims to explore changes in basal forebrain connectivity and glucose metabolism in Alzheimer's disease and their relationship with neurotransmitter distributions.
Forty-two Aβ-PET-positive Alzheimer's disease patients and forty-one healthy controls underwent simultaneous PET/MRI.
Resting-state functional connectivity of basal forebrain subregions was analyzed alongside cerebral glucose metabolism measured with 18F-FDG PET standardized uptake value ratio (SUVR).
Spatial correlations with neurotransmitter maps were assessed using the JuSpace toolbox.
AD patients exhibited decreased functional connectivity between the left Ch4 and hippocampus/posterior cingulate gyrus, and increased connectivity between the right Ch4 and precentral/postcentral gyrus (voxel-level p < 0.001).
Increased connectivity between left Ch1-3 and superior temporal gyrus/insula, along with decreased connectivity between right Ch1-3 and orbitofrontal gyrus, were observed.
Widespread cerebral hypometabolism was correlated with serotonin, dopamine, GABA, glutamate, and kappa-opioid systems (p < 0.05, FDR corrected).

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Randomized trial reveals altered functional connectivity and glucose metabolism in Alzheimer's patients, suggesting neurotransmitter involvement.

Cite This Study

He et al. (2026) studied this question.

synapsesocial.com/papers/6a01723a3a9f334c282725cb https://doi.org/10.1002/cns.70901

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial reveals altered functional connectivity and glucose metabolism in Alzheimer's patients, suggesting neurotransmitter involvement.

Correspondence of Basal Forebrain Resting‐State Functional Connectivity and Cerebral Glucose Metabolism Alterations With Neurotransmitter Maps in Alzheimer's Disease

Key Points

Discussion

Implication

Cite This Study

Correspondence of Basal Forebrain Resting‐State Functional Connectivity and Cerebral Glucose Metabolism Alterations With Neurotransmitter Maps in Alzheimer's Disease

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider