Reveals dynamics of αI integrins in response to ligands, indicating a new understanding of receptor activation.
Integrins are heterodimeric membrane proteins acting as mechanosensing receptors. Nine human α-subunits contain a ligand binding αI domain, but how ligands activate αI integrins are not understood. We present cryo-EM structures of the αI integrin α
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Lorentzen et al. (2026) studied this question.
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