OBJECTIVE: increases the risk of seizures in patients with glioma, and whether D2HG increases the electrical activity of neurons. METHODS: status. Rat cortical neurons were grown on microelectrode arrays, and their electrical activity was measured before and after treatment with exogenous D2HG, in the presence or absence of the selective NMDA antagonist, AP5. RESULTS: < 0.001). Exogenous D2HG increased the firing rate of cultured rat cortical neurons 4- to 6-fold, but was completely blocked by AP5. CONCLUSIONS: gliomas.
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Chen et al. (2017) studied this question.
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